diff --git a/pkgs/development/python-modules/pyvcf/default.nix b/pkgs/development/python-modules/pyvcf/default.nix
index 7c513617754f..919477298b15 100644
--- a/pkgs/development/python-modules/pyvcf/default.nix
+++ b/pkgs/development/python-modules/pyvcf/default.nix
@@ -28,5 +28,6 @@ buildPythonPackage rec {
       vcf will attempt to parse the content of each record based on the data
       types specified in the meta-information lines
     '';
+    broken = true; # uses the 2to3 feature, that got removed in setuptools 0.58
   };
 }