diff --git a/pkgs/development/libraries/sqlite/default.nix b/pkgs/development/libraries/sqlite/default.nix
index 6a278055e950..65ee34162a9d 100644
--- a/pkgs/development/libraries/sqlite/default.nix
+++ b/pkgs/development/libraries/sqlite/default.nix
@@ -110,6 +110,16 @@ stdenv.mkDerivation (finalAttrs: {
     })
   ];
 
+  # capi3c.test is a copy of capi3.test, but upstream only disabled the
+  # intentional use-after-free cases in the original. They segfault with
+  # allocators that return freed memory to the OS eagerly, such as musl's.
+  ${if stdenv.hostPlatform.isMusl then "postPatch" else null} = ''
+    substituteInPlace test/capi3c.test \
+      --replace-fail \
+        'if {[clang_sanitize_address]==0} {' \
+        'if {0 && [clang_sanitize_address]==0} {'
+  '';
+
   buildInputs = [
     zlib
   ]
@@ -199,6 +209,9 @@ stdenv.mkDerivation (finalAttrs: {
   doCheck = stdenv.hostPlatform.isLinux;
   # When tcl is not available, only run test targets that don't need it.
   checkTarget = lib.optionalString stdenv.hostPlatform.isStatic "fuzztest sourcetest";
+  # Neither GCC's libsanitizer nor compiler-rt's sanitizers are built for
+  # musl, so the fuzzcheck-asan and fuzzcheck-ubsan programs cannot be linked.
+  ${if stdenv.hostPlatform.isMusl then "checkFlags" else null} = [ "TSTRNNR_OPTS=~fuzzcheck-%san" ];
 
   passthru = {
     tests = {