diff --git a/pkgs/tools/networking/dd-agent/datadog-agent.nix b/pkgs/tools/networking/dd-agent/datadog-agent.nix
index ac35da0bbd3b..4aa7d70b1abc 100644
--- a/pkgs/tools/networking/dd-agent/datadog-agent.nix
+++ b/pkgs/tools/networking/dd-agent/datadog-agent.nix
@@ -1,4 +1,16 @@
-{ lib, buildGoModule, makeWrapper, fetchFromGitHub, pythonPackages, pkg-config, systemd, hostname, extraTags ? [] }:
+{ lib
+, stdenv
+, cmake
+, buildGoModule
+, makeWrapper
+, fetchFromGitHub
+, pythonPackages
+, pkg-config
+, systemd
+, hostname
+, withSystemd ? stdenv.isLinux
+, extraTags ? [ ]
+}:
 
 let
   # keep this in sync with github.com/DataDog/agent-payload dependency
@@ -7,18 +19,29 @@ let
   owner   = "DataDog";
   repo    = "datadog-agent";
   goPackagePath = "github.com/${owner}/${repo}";
-
-in buildGoModule rec {
-  pname = "datadog-agent";
-  version = "7.35.1";
+  version = "7.38.1";
 
   src = fetchFromGitHub {
     inherit owner repo;
     rev = version;
-    sha256 = "sha256-TvkPw67HBeRkKbbA3O/JVBkEUds36eW4UwKnRvPwAXc=";
+    sha256 = "sha256-bG8wsSQvZcG4/Th6mWVdVX9vpeYBZx8FxwdYXpIdXnU=";
+  };
+  rtloader = stdenv.mkDerivation {
+    pname = "datadog-agent-rtloader";
+    src = "${src}/rtloader";
+    inherit version;
+    nativeBuildInputs = [ cmake ];
+    buildInputs = [ python ];
+    cmakeFlags = ["-DBUILD_DEMO=OFF" "-DDISABLE_PYTHON2=ON"];
   };
 
-  vendorSha256 = "sha256-RmHxjJAMS+2MVoBJMD6FTQLhxDgzH3jtp87474i9ho8=";
+in buildGoModule rec {
+  pname = "datadog-agent";
+  inherit src version;
+
+  doCheck = false;
+
+  vendorSha256 = "sha256-bGDf48wFa32hURZfGN5pCMmslC3PeLNayKcl5cfjq9M=";
 
   subPackages = [
     "cmd/agent"
@@ -30,19 +53,29 @@ in buildGoModule rec {
 
 
   nativeBuildInputs = [ pkg-config makeWrapper ];
-  buildInputs = [ systemd ];
+  buildInputs = [rtloader] ++ lib.optionals withSystemd [ systemd ];
   PKG_CONFIG_PATH = "${python}/lib/pkgconfig";
 
-  preBuild = let
-    ldFlags = lib.concatStringsSep " " [
-      "-X ${goPackagePath}/pkg/version.Commit=${src.rev}"
-      "-X ${goPackagePath}/pkg/version.AgentVersion=${version}"
-      "-X ${goPackagePath}/pkg/serializer.AgentPayloadVersion=${payloadVersion}"
-      "-X ${goPackagePath}/pkg/collector/py.pythonHome=${python}"
-      "-r ${python}/lib"
-    ];
-  in ''
-    buildFlagsArray=( "-tags" "ec2 systemd cpython process log secrets ${lib.concatStringsSep " " extraTags}" "-ldflags" "${ldFlags}")
+  tags = [
+    "ec2"
+    "python"
+    "process"
+    "log"
+    "secrets"
+  ]
+  ++ lib.optionals withSystemd [ "systemd" ]
+  ++ extraTags;
+
+  ldflags = [
+    "-X ${goPackagePath}/pkg/version.Commit=${src.rev}"
+    "-X ${goPackagePath}/pkg/version.AgentVersion=${version}"
+    "-X ${goPackagePath}/pkg/serializer.AgentPayloadVersion=${payloadVersion}"
+    "-X ${goPackagePath}/pkg/collector/python.pythonHome3=${python}"
+    "-X ${goPackagePath}/pkg/config.DefaultPython=3"
+    "-r ${python}/lib"
+  ];
+
+  preBuild = ''
     # Keep directories to generate in sync with tasks/go.py
     go generate ./pkg/status ./cmd/agent/gui
   '';
diff --git a/pkgs/tools/networking/dd-agent/integrations-core.nix b/pkgs/tools/networking/dd-agent/integrations-core.nix
index d7dbb65b4f58..ca1ffa3f2559 100644
--- a/pkgs/tools/networking/dd-agent/integrations-core.nix
+++ b/pkgs/tools/networking/dd-agent/integrations-core.nix
@@ -42,20 +42,15 @@ let
     owner = "DataDog";
     repo = "integrations-core";
     rev = version;
-    sha256 = "0424zsnf747s10kfzv5y0m0ac9sgczip78yvghhrc2i089i5z2h4";
+    sha256 = "sha256-CIzuJ97KwsG1k65Y+8IUSka/3JX1pmQKN3hPHzZnGhQ=";
   };
-  version = "7.30.1";
+  version = "7.38.0";
 
   # Build helper to build a single datadog integration package.
   buildIntegration = { pname, ... }@args: python.pkgs.buildPythonPackage (args // {
     inherit src version;
     name = "datadog-integration-${pname}-${version}";
 
-    postPatch = ''
-      # jailbreak install_requires
-      sed -i 's/==.*//' requirements.in
-      cp requirements.in requirements.txt
-    '';
     sourceRoot = "source/${args.sourceRoot or pname}";
     doCheck = false;
   });
@@ -65,7 +60,21 @@ let
     pname = "checks-base";
     sourceRoot = "datadog_checks_base";
     propagatedBuildInputs = with python.pkgs; [
-      requests protobuf prometheus-client simplejson uptime
+      cachetools
+      cryptography
+      immutables
+      jellyfish
+      prometheus-client
+      protobuf
+      pydantic
+      python-dateutil
+      pyyaml
+      requests
+      requests-toolbelt
+      requests-unixsocket
+      simplejson
+      uptime
+      wrapt
     ];
   };
 
@@ -75,8 +84,8 @@ let
     mongo    = (ps: [ ps.pymongo ]);
     network  = (ps: [ ps.psutil ]);
     nginx    = (ps: []);
-    postgres = (ps: with ps; [ pg8000 psycopg2 ]);
-    process  = (ps: []);
+    postgres = (ps: with ps; [ pg8000 psycopg2 semver ]);
+    process  = (ps: [ ps.psutil]);
   };
 
   # All integrations (default + extra):