diff --git a/pkgs/development/python-modules/opuslib/default.nix b/pkgs/development/python-modules/opuslib/default.nix
index 79583ee926f6..a9c33f5abab4 100644
--- a/pkgs/development/python-modules/opuslib/default.nix
+++ b/pkgs/development/python-modules/opuslib/default.nix
@@ -1,5 +1,6 @@
 { buildPythonPackage,
   fetchFromGitHub,
+  fetchpatch,
   isPy27,
   libopus,
   nose,
@@ -21,6 +22,12 @@ buildPythonPackage rec {
   };
 
   patches = [
+    # https://github.com/orion-labs/opuslib/pull/22
+    (fetchpatch {
+      name = "fix-variadic-functions-on-aarch64-darwin.patch";
+      url = "https://github.com/orion-labs/opuslib/commit/8aee916e4da4b3183d49cff5a986dc2408076d8d.patch";
+      hash = "sha256-oa1HCFHNS3ejzSf0jxv9NueUKOZgdCtpv+xTrjYW5os=";
+    })
     (substituteAll {
       src = ./opuslib-paths.patch;
       opusLibPath = "${libopus}/lib/libopus${stdenv.hostPlatform.extensions.sharedLibrary}";