diff --git a/pkgs/development/python-modules/mosek/default.nix b/pkgs/development/python-modules/mosek/default.nix
new file mode 100644
index 000000000000..e8d2cb3c9887
--- /dev/null
+++ b/pkgs/development/python-modules/mosek/default.nix
@@ -0,0 +1,90 @@
+{
+  autoPatchelfHook,
+  buildPythonPackage,
+  fetchurl,
+  lib,
+  numpy,
+  onetbb,
+  python,
+  pythonOlder,
+  setuptools,
+  stdenv,
+}:
+
+buildPythonPackage (
+  finalAttrs:
+  let
+    mosek-major-minor = lib.versions.majorMinor finalAttrs.version;
+    python-major-version = python.sourceVersion.major;
+
+    mosek-libs = stdenv.mkDerivation {
+      pname = "mosek-libs";
+      inherit (finalAttrs) version src;
+      nativeBuildInputs = [
+        onetbb
+        autoPatchelfHook
+      ];
+
+      # Copy the vendor mosek library, which will optionally use a tbb that
+      # is located next to it. We should use our own packaged one, even though
+      # that is 2021.11.0 (libtbb.so.12.11) instead of the packaged 2021.12.0 (libtbb.so.12.12).
+      # The packaged tbb would need to be patchelfed to find libstdc++ and would lead
+      # with clashes with other code using the nix based tbb, used in rtech for example.
+      installPhase = ''
+        mkdir -p $out/lib
+        cp ${mosek-major-minor}/tools/platform/linux64x86/bin/libmosek64.so.${mosek-major-minor} $out/lib/
+        ln -snf ${onetbb}/lib/libtbb.so.12 $out/lib/libtbb.so.12
+      '';
+    };
+  in
+  {
+    pname = "mosek";
+    version = "11.2.2";
+    pyproject = true;
+    build-system = [ setuptools ];
+
+    # MOSEK ships pre-built C extensions; minimum supported Python is 3.9
+    disabled = pythonOlder "3.9";
+
+    src = fetchurl {
+      url = "https://download.mosek.com/stable/${finalAttrs.version}/mosektoolslinux64x86.tar.bz2";
+      sha256 = "sha256-DVSZ+8ggmK7EyiaHYCUjxQ/3mY5GcUlgXVRfReiBkiw=";
+    };
+
+    # Move the source we want to the root
+    prePatch = ''
+      mv ${mosek-major-minor}/tools/platform/linux64x86/python/${python-major-version}/* .
+    '';
+
+    # Disable part of setup.py that 'fixes' library paths based on installation
+    # location (which it gets wrong for a Nix build). Rely on autoPatchelfHook
+    # instead. Also disable installation of _mskpreload.py, which tries to preload
+    # dependent libraries and again gets the location wrong, and seems dangerous
+    # anyway.
+    postPatch = ''
+      sed -i -e 's/^\(\s*\)#\?\(self.execute(self.install_\(libs\|preloader\),\)/\1#\2/' setup.py
+    '';
+
+    nativeBuildInputs = [
+      autoPatchelfHook
+    ];
+
+    propagatedBuildInputs = [
+      mosek-libs
+      numpy
+    ];
+
+    # No tests are supplied
+    doCheck = false;
+
+    pythonImportsCheck = [ "mosek" ];
+
+    meta = with lib; {
+      description = "Python interface for MOSEK - the package for large scale convex, conic and mixed-integer optimization.";
+      homepage = "https://www.mosek.com/";
+      changelog = "https://docs.mosek.com/${mosek-major-minor}/releasenotes/changes.html";
+      license = licenses.unfree;
+      maintainers = with maintainers; [ jherland ];
+    };
+  }
+)
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 6fc262ac8c1c..f5a90b8cdf4d 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -11207,6 +11207,8 @@ self: super: with self; {
 
   mortgage = callPackage ../development/python-modules/mortgage { };
 
+  mosek = callPackage ../development/python-modules/mosek { };
+
   motionblinds = callPackage ../development/python-modules/motionblinds { };
 
   motionblindsble = callPackage ../development/python-modules/motionblindsble { };