diff --git a/pkgs/development/python-modules/cryptography/default.nix b/pkgs/development/python-modules/cryptography/default.nix
index 148402b9ce78..f0560b576078 100644
--- a/pkgs/development/python-modules/cryptography/default.nix
+++ b/pkgs/development/python-modules/cryptography/default.nix
@@ -22,19 +22,19 @@
 
 buildPythonPackage rec {
   pname = "cryptography";
-  version = "48.0.0";
+  version = "49.0.0";
   pyproject = true;
 
   src = fetchFromGitHub {
     owner = "pyca";
     repo = "cryptography";
     tag = version;
-    hash = "sha256-S1oOLou6tE1atqZ6HXwVQDps9BnjiEpRdoZY5VQm+Kg=";
+    hash = "sha256-yHUIGauFZYnjcoROvocT1UqQ0B8ZuVTaJ0ZAfri6T1E=";
   };
 
   cargoDeps = rustPlatform.fetchCargoVendor {
     inherit pname version src;
-    hash = "sha256-mp+1Fw8xNBJD1DM8obAqYBP8erxXiP768+ifqRN1Uqs=";
+    hash = "sha256-yMCBu/RGRcEQST8tEWCNgVvlQsp2KamOqt60qvOYdt8=";
   };
 
   patches = [