diff --git a/pkgs/development/python-modules/asdf-astropy/default.nix b/pkgs/development/python-modules/asdf-astropy/default.nix
new file mode 100644
index 000000000000..1ee09ad98332
--- /dev/null
+++ b/pkgs/development/python-modules/asdf-astropy/default.nix
@@ -0,0 +1,70 @@
+{
+  lib,
+  asdf-coordinates-schemas,
+  asdf-standard,
+  asdf-transform-schemas,
+  asdf,
+  astropy,
+  buildPythonPackage,
+  fetchFromGitHub,
+  numpy,
+  packaging,
+  pytest-astropy,
+  pytestCheckHook,
+  pythonOlder,
+  scipy,
+  setuptools-scm,
+  setuptools,
+  tomli,
+  wheel,
+}:
+
+buildPythonPackage rec {
+  pname = "asdf-astropy";
+  version = "0.6.1";
+  pyproject = true;
+
+  disabled = pythonOlder "3.10";
+
+  src = fetchFromGitHub {
+    owner = "astropy";
+    repo = "asdf-astropy";
+    rev = "refs/tags/${version}";
+    hash = "sha256-dOd9QdBOu7QotRiHkXJoIqaHG6U9odTlRmy22/nvvuw=";
+  };
+
+  nativeBuildInputs = [
+    setuptools
+    setuptools-scm
+  ];
+
+  propagatedBuildInputs = [
+    asdf
+    asdf-coordinates-schemas
+    asdf-standard
+    asdf-transform-schemas
+    astropy
+    numpy
+    packaging
+  ];
+
+  nativeCheckInputs = [
+    pytest-astropy
+    pytestCheckHook
+    scipy
+  ];
+
+  pythonImportsCheck = [ "asdf_astropy" ];
+
+  preCheck = ''
+    export HOME=$(mktemp -d)
+  '';
+
+  meta = with lib; {
+    description = "Extension library for ASDF to provide support for Astropy";
+    homepage = "https://github.com/astropy/asdf-astropy";
+    changelog = "https://github.com/astropy/asdf-astropy/blob/${version}/CHANGES.rst";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 2970b7abed7f..f3e2c010c15f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -787,6 +787,8 @@ self: super: with self; {
 
   asdf = callPackage ../development/python-modules/asdf { };
 
+  asdf-astropy = callPackage ../development/python-modules/asdf-astropy { };
+
   asdf-coordinates-schemas = callPackage ../development/python-modules/asdf-coordinates-schemas { };
 
   asdf-standard = callPackage ../development/python-modules/asdf-standard { };