diff --git a/pkgs/development/python-modules/showit/default.nix b/pkgs/development/python-modules/showit/default.nix
deleted file mode 100644
index 5d22ce607c53..000000000000
--- a/pkgs/development/python-modules/showit/default.nix
+++ /dev/null
@@ -1,42 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  setuptools,
-  numpy,
-  matplotlib,
-  pytestCheckHook,
-}:
-
-buildPythonPackage {
-  pname = "showit";
-  version = "1.1.4";
-  pyproject = true;
-
-  __structuredAttrs = true;
-
-  src = fetchFromGitHub {
-    owner = "freeman-lab";
-    repo = "showit";
-    rev = "ef76425797c71fbe3795b4302c49ab5be6b0bacb"; # no tags in repo
-    hash = "sha256-JrcqfQtSjbbOhr5quHE+QwlKsA6eUpCifLRzTrOOqHU=";
-  };
-
-  build-system = [ setuptools ];
-
-  dependencies = [
-    numpy
-    matplotlib
-  ];
-
-  nativeCheckInputs = [ pytestCheckHook ];
-
-  pythonImportsCheck = [ "showit" ];
-
-  meta = {
-    description = "Simple and sensible display of images";
-    homepage = "https://github.com/freeman-lab/showit";
-    license = lib.licenses.mit;
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/development/python-modules/slicedimage/default.nix b/pkgs/development/python-modules/slicedimage/default.nix
deleted file mode 100644
index c770f9cd8e70..000000000000
--- a/pkgs/development/python-modules/slicedimage/default.nix
+++ /dev/null
@@ -1,53 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  boto3,
-  diskcache,
-  packaging,
-  numpy,
-  requests,
-  scikit-image,
-  six,
-  pytestCheckHook,
-  tifffile,
-}:
-
-buildPythonPackage rec {
-  pname = "slicedimage";
-  version = "4.1.1";
-  format = "setuptools";
-
-  src = fetchFromGitHub {
-    owner = "spacetx";
-    repo = "slicedimage";
-    rev = version;
-    sha256 = "1vpg8varvfx0nj6xscdfm7m118hzsfz7qfzn28r9rsfvrhr0dlcw";
-  };
-
-  propagatedBuildInputs = [
-    boto3
-    diskcache
-    packaging
-    numpy
-    requests
-    scikit-image
-    six
-    tifffile
-  ];
-
-  nativeCheckInputs = [ pytestCheckHook ];
-
-  # Ignore tests which require setup, check again if disabledTestFiles can be used
-  disabledTestPaths = [ "tests/io_" ];
-
-  pythonImportsCheck = [ "slicedimage" ];
-
-  meta = {
-    description = "Library to access sliced imaging data";
-    mainProgram = "slicedimage";
-    homepage = "https://github.com/spacetx/slicedimage";
-    license = lib.licenses.mit;
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index a035320ad2b5..10a3efcd75a2 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -657,10 +657,12 @@ mapAliases {
   setuptoolsTrial = throw "'setuptoolsTrial' has been renamed to/replaced by 'setuptools-trial'"; # Converted to throw 2025-10-29
   sharkiqpy = throw "'sharkiqpy' has been renamed to/replaced by 'sharkiq'"; # Converted to throw 2025-10-29
   shippai = throw "shippai has been removed because the upstream repository was archived in 2023"; # added 2025-07-09
+  showit = throw "'showit' has been removed because the upstream is unmaintained"; # Added 2026-08-14
   sip_4 = throw "'sip_4' has been renamed to/replaced by 'sip4'"; # Converted to throw 2025-10-29
   sipsimple = lib.warnOnInstantiate "'sipsimple' has been renamed to 'python3-sipsimple' to fit upstream naming" python3-sipsimple; # added 2026-01-05
   slackclient = throw "'slackclient' has been renamed to/replaced by 'slack-sdk'"; # Converted to throw 2025-10-29
   sleekxmpp = throw "'sleekxmpp' has been removed because it was deprecated in favor of 'slixmpp'"; # added 2026-01-19
+  slicedimage = throw "'slicedimage' has been removed because it was unused"; # Added 2026-08-14
   smart_open = throw "'smart_open' has been renamed to/replaced by 'smart-open'"; # Converted to throw 2025-10-29
   smpp_pdu = throw "'smpp_pdu' has been renamed to/replaced by 'smpp-pdu'"; # Converted to throw 2025-10-29
   sorl_thumbnail = throw "'sorl_thumbnail' has been renamed to/replaced by 'sorl-thumbnail'"; # Converted to throw 2025-10-29
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index ee48a5f90e87..e64c00c07de3 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -18656,8 +18656,6 @@ self: super: with self; {
 
   show-in-file-manager = callPackage ../development/python-modules/show-in-file-manager { };
 
-  showit = callPackage ../development/python-modules/showit { };
-
   shtab = callPackage ../development/python-modules/shtab { };
 
   shutilwhich = callPackage ../development/python-modules/shutilwhich { };
@@ -18874,8 +18872,6 @@ self: super: with self; {
 
   slh-dsa = callPackage ../development/python-modules/slh-dsa { };
 
-  slicedimage = callPackage ../development/python-modules/slicedimage { };
-
   slicer = callPackage ../development/python-modules/slicer { };
 
   slicerator = callPackage ../development/python-modules/slicerator { };