diff --git a/pkgs/development/python-modules/derpconf/default.nix b/pkgs/development/python-modules/derpconf/default.nix
deleted file mode 100644
index 544b461fe7c7..000000000000
--- a/pkgs/development/python-modules/derpconf/default.nix
+++ /dev/null
@@ -1,29 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchPypi,
-  six,
-}:
-
-buildPythonPackage rec {
-  pname = "derpconf";
-  version = "0.8.4";
-  format = "setuptools";
-
-  src = fetchPypi {
-    inherit pname version;
-    hash = "sha256-66MOqcWIiqJrORJDgAH5iUblHyqJvuf9DIBN56XjKwU=";
-  };
-
-  propagatedBuildInputs = [ six ];
-
-  pythonImportsCheck = [ "derpconf" ];
-
-  meta = {
-    description = "Module to abstract loading configuration files for your app";
-    homepage = "https://github.com/globocom/derpconf";
-    changelog = "https://github.com/globocom/derpconf/releases/tag/${version}";
-    license = lib.licenses.mit;
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 2779c801ec9d..93a7270ced57 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -185,6 +185,7 @@ mapAliases {
   debian = throw "'debian' has been renamed to/replaced by 'python-debian'"; # Converted to throw 2025-10-29
   dedupe-pylbfgs = pylbfgs; # added 2026-06-28
   deepsearch-glm = throw "'deepsearch-glm' has been removed due to lack of upstream maintenance"; # Added 2025-03-04
+  derpconf = throw "'derpconf' has been removed because it is unmaintained upstream"; # Added 2026-09-05
   dictionaries = throw "'dictionaries' has been removed as it was archived upstream"; # Added 2026-07-20
   dictpath = throw "'dictpath' has been renamed to/replaced by 'pathable'"; # Converted to throw 2025-10-29
   diff_cover = throw "'diff_cover' has been renamed to/replaced by 'diff-cover'"; # Converted to throw 2025-10-29
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b518d3c17f86..252263461245 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -4308,8 +4308,6 @@ self: super: with self; {
 
   derivative = callPackage ../development/python-modules/derivative { };
 
-  derpconf = callPackage ../development/python-modules/derpconf { };
-
   desktop-entry-lib = callPackage ../development/python-modules/desktop-entry-lib { };
 
   desktop-notifier = callPackage ../development/python-modules/desktop-notifier { };