diff --git a/pkgs/development/ocaml-modules/ocamlfuse/default.nix b/pkgs/development/ocaml-modules/ocamlfuse/default.nix
deleted file mode 100644
index 977bf64866e2..000000000000
--- a/pkgs/development/ocaml-modules/ocamlfuse/default.nix
+++ /dev/null
@@ -1,40 +0,0 @@
-{
-  lib,
-  buildDunePackage,
-  fetchFromGitHub,
-  camlidl,
-  fuse,
-  dune-configurator,
-}:
-
-buildDunePackage (finalAttrs: {
-  pname = "ocamlfuse";
-  version = "2.7.1_cvs13";
-
-  src = fetchFromGitHub {
-    owner = "astrada";
-    repo = "ocamlfuse";
-    rev = "v${finalAttrs.version}";
-    hash = "sha256-h1ExohTlr1gP2DwHKQW3PTwz6d3pust5gdeyTHJ2KBk=";
-  };
-
-  postPatch = ''
-    substituteInPlace lib/Fuse_main.c \
-      --replace-warn "<fuse_lowlevel.h>" "<fuse/fuse_lowlevel.h>"
-  '';
-
-  nativeBuildInputs = [ camlidl ];
-  buildInputs = [ dune-configurator ];
-  propagatedBuildInputs = [
-    camlidl
-    fuse
-  ];
-
-  meta = {
-    homepage = "https://sourceforge.net/projects/ocamlfuse";
-    description = "OCaml bindings for FUSE";
-    license = lib.licenses.gpl2;
-    platforms = lib.platforms.linux;
-    maintainers = with lib.maintainers; [ bennofs ];
-  };
-})
diff --git a/pkgs/top-level/ocaml-packages.nix b/pkgs/top-level/ocaml-packages.nix
index 7e85b77a462a..ba3abf469dce 100644
--- a/pkgs/top-level/ocaml-packages.nix
+++ b/pkgs/top-level/ocaml-packages.nix
@@ -1574,8 +1574,6 @@ let
           callPackage ../development/ocaml-modules/ocamlformat/ocamlformat-rpc-lib.nix
             { };
 
-        ocamlfuse = callPackage ../development/ocaml-modules/ocamlfuse { };
-
         ocamlgraph = callPackage ../development/ocaml-modules/ocamlgraph { };
         ocamlgraph_gtk = callPackage ../development/ocaml-modules/ocamlgraph/gtk.nix { };
 
@@ -2394,6 +2392,7 @@ let
         ocaml-vdom = throw "2023-10-09: ocamlPackages.ocaml-vdom was renamed to ocamlPackages.vdom";
         ocaml_lwt = throw "ocamlPackages.ocaml_lwt has been renamed to ocamlPackages.lwt"; # Added 2025-12-05
         ocaml_mysql = throw "ocamlPackages.ocaml_mysql is not maintained, use ocamlPackages.mariadb instead";
+        ocamlfuse = throw "ocamlPackages.ocamlfuse has been removed as it depends on fuse2";
         torch = throw "ocamlPackages.torch has been removed due to being broken for more than a year; see RFC 180"; # Added 2026-02-05
       }
     )).overrideScope