diff --git a/pkgs/by-name/ci/ciopfs/package.nix b/pkgs/by-name/ci/ciopfs/package.nix
deleted file mode 100644
index c910fcd15088..000000000000
--- a/pkgs/by-name/ci/ciopfs/package.nix
+++ /dev/null
@@ -1,38 +0,0 @@
-{
-  lib,
-  stdenv,
-  fetchurl,
-  pkg-config,
-  fuse,
-  glib,
-  attr,
-}:
-
-stdenv.mkDerivation (finalAttrs: {
-  pname = "ciopfs";
-  version = "0.4";
-
-  src = fetchurl {
-    url = "https://www.brain-dump.org/projects/ciopfs/ciopfs-${finalAttrs.version}.tar.gz";
-    sha256 = "0sr9i9b3qfwbfvzvk00yrrg3x2xqk1njadbldkvn7hwwa4z5bm9l";
-  };
-
-  nativeBuildInputs = [ pkg-config ];
-  buildInputs = [
-    fuse
-    glib
-    attr
-  ];
-
-  makeFlags = [
-    "DESTDIR=$(out)"
-    "PREFIX="
-  ];
-
-  meta = {
-    homepage = "https://www.brain-dump.org/projects/ciopfs/";
-    description = "Case-insensitive filesystem layered on top of any other filesystem";
-    license = lib.licenses.gpl2Only;
-    platforms = lib.platforms.linux;
-  };
-})
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 461179a42573..7e5b83973ebc 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -479,6 +479,7 @@ mapAliases {
   chrome-gnome-shell = throw "'chrome-gnome-shell' has been renamed to/replaced by 'gnome-browser-connector'"; # Converted to throw 2025-10-27
   ci-edit = throw "'ci-edit' has been removed due to lack of maintenance upstream"; # Added 2025-08-26
   cinnamon-common = cinnamon; # Added 2025-08-06
+  ciopfs = throw "'ciopfs' has been removed due to lack of fuse 3 support."; # Added 2026-06-05
   cisco-packet-tracer_8 = throw "'cisco-packet-tracer_8' has been removed as it vendored qt5 webengine. Consider updating to 'cisco-packet-tracer_9' instead."; # Added 2026-04-26
   ciscoPacketTracer7 = throw "'ciscoPacketTracer7' has been removed in favor of 'cisco-packet-tracer_8' and 'cisco-packet-tracer_9'";
   ciscoPacketTracer8 = cisco-packet-tracer_8; # Added 2026-02-08