diff --git a/pkgs/development/python-modules/n3fit/default.nix b/pkgs/development/python-modules/n3fit/default.nix
deleted file mode 100644
index 01c56659465c..000000000000
--- a/pkgs/development/python-modules/n3fit/default.nix
+++ /dev/null
@@ -1,51 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  hyperopt,
-  keras,
-  nnpdf,
-  psutil,
-  tensorflow,
-  validphys2,
-}:
-
-buildPythonPackage rec {
-  pname = "n3fit";
-  version = "4.0";
-  format = "setuptools";
-
-  inherit (nnpdf) src;
-
-  prePatch = ''
-    cd n3fit
-  '';
-
-  postPatch = ''
-    substituteInPlace src/n3fit/version.py \
-      --replace '= __give_git()' '= "'$version'"'
-  '';
-
-  propagatedBuildInputs = [
-    hyperopt
-    keras
-    psutil
-    tensorflow
-    validphys2
-  ];
-
-  postInstall = ''
-    for prog in "$out"/bin/*; do
-      wrapProgram "$prog" --set PYTHONPATH "$PYTHONPATH:$(toPythonPath "$out")"
-    done
-  '';
-
-  doCheck = false; # no tests
-  pythonImportsCheck = [ "n3fit" ];
-
-  meta = with lib; {
-    description = "NNPDF fitting framework";
-    homepage = "https://docs.nnpdf.science";
-    inherit (nnpdf.meta) license;
-    maintainers = with maintainers; [ veprbl ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index c803165a1d7e..acd9f4d6bce7 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -327,6 +327,7 @@ mapAliases ({
   mrkd = throw "mrkd has been promoted to a top-level attribute name: `pkgs.mrkd`"; # added 2023-08-01
   multi_key_dict = multi-key-dict; # added 2023-11-05
   mutmut = throw "mutmut has been promoted to a top-level attribute name: `pkgs.mutmut`"; # added 2022-10-02
+  n3fit = throw "n3fit has been removed since it relies on a dependency that was removed"; # added 2024-08-24
   nbmerge = throw "nbmerge has moved to pkgs.nbmerge"; # added 2024-07-05
   net2grid = gridnet; # add 2022-04-22
   nghttp2 = throw "in 1.52.0 removed deprecated python bindings."; # added 2023-06-08
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 5f7b753ce9fa..f4e874480b5a 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8934,8 +8934,6 @@ self: super: with self; {
 
   myuplink = callPackage ../development/python-modules/myuplink { };
 
-  n3fit = callPackage ../development/python-modules/n3fit { };
-
   nad-receiver = callPackage ../development/python-modules/nad-receiver { };
 
   nagiosplugin = callPackage ../development/python-modules/nagiosplugin { };