diff --git a/pkgs/development/python-modules/vxi11/default.nix b/pkgs/development/python-modules/vxi11/default.nix
index c7950914b3fd..b99b3e2505ea 100644
--- a/pkgs/development/python-modules/vxi11/default.nix
+++ b/pkgs/development/python-modules/vxi11/default.nix
@@ -1,6 +1,7 @@
 {
   lib,
   buildPythonPackage,
+  pythonAtLeast,
   fetchFromGitHub,
   pytestCheckHook,
   fetchpatch2,
@@ -11,6 +12,9 @@ buildPythonPackage rec {
   version = "0.9";
   format = "setuptools";
 
+  # vxi11 relies on xdrlib, which was removed in Python 3.13
+  disabled = pythonAtLeast "3.13";
+
   # no tests in PyPI tarball
   src = fetchFromGitHub {
     owner = "python-ivi";