diff --git a/pkgs/by-name/xp/xpra/fix-122159.patch b/pkgs/by-name/xp/xpra/fix-122159.patch
index ae1b27e2bda5..ceb90cc2af10 100644
--- a/pkgs/by-name/xp/xpra/fix-122159.patch
+++ b/pkgs/by-name/xp/xpra/fix-122159.patch
@@ -1,6 +1,6 @@
 --- a/xpra/scripts/main.py
 +++ b/xpra/scripts/main.py
-@@ -536,13 +536,7 @@
+@@ -526,13 +526,7 @@
              "upgrade", "upgrade-seamless", "upgrade-desktop",
              "encoder", "runner",
      ) and not display_is_remote and options.daemon and use_systemd_run(options.systemd_run):
@@ -8,9 +8,9 @@
 -        # inject it into the command line if we have to:
          argv = list(cmdline)
 -        if argv[0].find("python") < 0:
--            major, minor = sys.version_info.major, sys.version_info.minor
--            python = which("python%i.%i" % (major, minor)) or which("python%i" % major) or which("python") or "python"
--            argv.insert(0, python)
+-            from xpra.platform.paths import get_python_execfile_command
+-            for arg in reversed(get_python_execfile_command()):
+-                argv.insert(0, arg)
          return systemd_run_wrap(mode, argv, options.systemd_run_args, user=getuid() != 0)
      configure_env(options.env)
      configure_logging(options, mode)
diff --git a/pkgs/by-name/xp/xpra/package.nix b/pkgs/by-name/xp/xpra/package.nix
index bcd5776b7d21..da038f7556a2 100644
--- a/pkgs/by-name/xp/xpra/package.nix
+++ b/pkgs/by-name/xp/xpra/package.nix
@@ -1,6 +1,7 @@
 {
   lib,
   fetchFromGitHub,
+  nix-update-script,
   pkg-config,
   runCommand,
   writeText,
@@ -104,14 +105,14 @@ let
 in
 effectiveBuildPythonApplication rec {
   pname = "xpra";
-  version = "6.4.4";
+  version = "6.5.3";
   format = "setuptools";
 
   src = fetchFromGitHub {
     owner = "Xpra-org";
     repo = "xpra";
     tag = "v${version}";
-    hash = "sha256-zDI6xksviTjsfsh5OJdkif24BGPW9zfDsxATC98eeX0=";
+    hash = "sha256-UDKnkynWoS1feUBRRHXl7emksUmufBL16gmVFslMHpM=";
   };
 
   patches = [
@@ -120,7 +121,7 @@ effectiveBuildPythonApplication rec {
   ];
 
   postPatch = lib.optionalString stdenv.hostPlatform.isLinux ''
-    substituteInPlace xpra/platform/posix/features.py \
+    substituteInPlace xpra/scripts/config.py \
       --replace-fail "/usr/bin/xdg-open" "${xdg-utils}/bin/xdg-open"
 
     patchShebangs --build fs/bin/build_cuda_kernels.py
@@ -290,7 +291,7 @@ effectiveBuildPythonApplication rec {
 
   passthru = {
     inherit xf86videodummy;
-    updateScript = ./update.sh;
+    updateScript = nix-update-script { };
   };
 
   meta = {
diff --git a/pkgs/by-name/xp/xpra/update.sh b/pkgs/by-name/xp/xpra/update.sh
deleted file mode 100755
index c1b408a0beef..000000000000
--- a/pkgs/by-name/xp/xpra/update.sh
+++ /dev/null
@@ -1,5 +0,0 @@
-#!/usr/bin/env nix-shell
-#!nix-shell -i bash -p curl perl common-updater-scripts
-
-version=$(curl https://xpra.org/src/ | perl -ne 'print "$1\n" if /xpra-([[:digit:].]+)\./' | sort -V | tail -n1)
-update-source-version xpra "$version"