diff --git a/doc/languages-frameworks/python.section.md b/doc/languages-frameworks/python.section.md
index 099f933870cb..ecda096fd2a2 100644
--- a/doc/languages-frameworks/python.section.md
+++ b/doc/languages-frameworks/python.section.md
@@ -163,8 +163,85 @@ following are specific to `buildPythonPackage`:
 
 * `catchConflicts ? true`: If `true`, abort package build if a package name
   appears more than once in dependency tree. Default is `true`.
-* `disabled ? false`: If `true`, package is not built for the particular Python
-  interpreter version.
+* `disabled ? false`:
+  If set to `true` for a particular Python interpreter version or implementation, the package is marked with `meta.problems.unsupportedPython`, and will throw an error message complaining the Python interpreter being unsupported during package instantiation.
+
+  ```nix
+  {
+    lib,
+    pythonAtLeast,
+    buildPythonPackage,
+    fetchFromGitHub,
+    setuptools,
+  }:
+  buildPythonPackage (finalAttrs: {
+    pname = "coconut";
+    version = "3.1.2";
+    pyproject = true;
+
+    src = fetchFromGitHub {
+      owner = "evhub";
+      repo = "coconut";
+      tag = "v${finalAttrs.version}";
+      hash = "sha256-Vd6ZY3PlbPOy63/0/0YJ1U2PpsVdctOoInyKftj//cM=";
+    };
+
+    disabled = pythonAtLeast "3.13";
+
+    build-system = [
+      setuptools
+    ];
+
+    meta = {
+      homepage = "http://coconut-lang.org/";
+    };
+  })
+  ```
+
+  One can also choose to mark a package with `meta.problems.unsupportedPython` providing a custom `message` and optional `urls`:
+
+  ```nix
+  {
+    lib,
+    python,
+    pythonAtLeast,
+    buildPythonPackage,
+    fetchFromGitHub,
+    setuptools,
+  }:
+  buildPythonPackage (finalAttrs: {
+    pname = "coconut";
+    version = "3.1.2";
+    pyproject = true;
+
+    src = fetchFromGitHub {
+      owner = "evhub";
+      repo = "coconut";
+      tag = "v${finalAttrs.version}";
+      hash = "sha256-Vd6ZY3PlbPOy63/0/0YJ1U2PpsVdctOoInyKftj//cM=";
+    };
+
+    build-system = [
+      setuptools
+    ];
+
+    meta = {
+      homepage = "http://coconut-lang.org/";
+      problems.unsupportedPython = lib.optionalAttrs (pythonAtLeast "3.13") {
+        message = lib.removePrefix (python.libPrefix + "-") finalAttrs.name + " requires Python <3.13";
+        urls = [
+          "https://github.com/evhub/coconut/issues/873"
+        ];
+      };
+    };
+  })
+  ```
+
+  ::: {.note}
+  Referencing `<pkg>.disabled` or `finalAtts.disabled` for Python packages are deprecated.
+  Use `<pkg> ? meta.problems.unsupportedPython` instead (the same goes with `finalAttrs`).
+  :::
+
 * `dontWrapPythonPrograms ? false`: Skip wrapping of Python programs.
 * `permitUserSite ? false`: Skip setting the `PYTHONNOUSERSITE` environment
   variable in wrapped programs.
diff --git a/doc/release-notes/rl-2611.section.md b/doc/release-notes/rl-2611.section.md
index f0e70c04ec4f..cf0640dcb311 100644
--- a/doc/release-notes/rl-2611.section.md
+++ b/doc/release-notes/rl-2611.section.md
@@ -255,6 +255,12 @@
 - `swiftpm` is no longer wrapped to include Git to fetch dependencies.
   Users with Git-based dependencies will need to add `git` to their dev shells or include it in their environment if they weren’t already.
 
+- `buildPythonPackage` and `buildPythonApplication` now uses `meta.problems.unsupportedPython` to mark Python packages with unsupported Python interpreters.
+  - The `disabled` argument automatically converts to `meta.problems.unsupportedPython` with the default message.
+  - Overriding the `passthru.disabled` attribute no longer affects such marks.
+  - `<pkg> ? meta.problems.unsupportedPython` is now the canonical way to identify if the package uses an incompatible Python interpreter.
+    The `passthru.disabled` attribute is deprecated and will be removed in future releases.
+
 - `vimacs` has been removed, as it has not been maintained in 10 years and was built for an old version of vim (6.0).
 
 - The deprecated `appimageTools.extractType1`, `appimageTools.extractType2`, and `appimageTools.wrapType1` aliases now emit warnings. Use `appimageTools.extract` and `appimageTools.wrapType2` instead.
diff --git a/pkgs/development/interpreters/python/mk-python-derivation.nix b/pkgs/development/interpreters/python/mk-python-derivation.nix
index eee99a70d25c..9eb202996e14 100644
--- a/pkgs/development/interpreters/python/mk-python-derivation.nix
+++ b/pkgs/development/interpreters/python/mk-python-derivation.nix
@@ -418,12 +418,14 @@ lib.extendMkDerivation {
 
       passthru = {
         inherit
-          disabled
           pyproject
           build-system
           dependencies
           optional-dependencies
           ;
+
+        disabled = finalAttrs ? meta.problems.unsupportedPython;
+
         updateScript = nix-update-script { };
         # __stdenvPythonCompat[Pos] attributes are here for overrideStdenvCompat in `python-packages-base.nix` to work.
         # They are internal and subject to changes.
@@ -439,7 +441,22 @@ lib.extendMkDerivation {
         platforms = python.meta.platforms;
         isBuildPythonPackage = python.meta.platforms;
       }
-      // meta;
+      // meta
+      // {
+        problems =
+          let
+            disabled' = meta ? problems.unsupportedPython || disabled;
+          in
+          meta.problems or { }
+          // {
+            ${if disabled' then "unsupportedPython" else null} = meta.problems.unsupportedPython or { } // {
+              kind = "broken";
+              message =
+                meta.problems.unsupportedPython.message
+                  or "${removePrefix namePrefix finalAttrs.name} not supported for interpreter ${python.executable}";
+            };
+          };
+      };
     }
     // optionalAttrs (attrs ? checkPhase) {
       # If given use the specified checkPhase, otherwise use the setup hook.
@@ -475,20 +492,5 @@ lib.extendMkDerivation {
 
   # This derivation transformation function must be independent to `attrs`
   # for fixed-point arguments support in the future.
-  transformDrv =
-    let
-      # Workaround to make the `lib.extendDerivation`-based disabled functionality
-      # respect `<pkg>.overrideAttrs`
-      # It doesn't cover `<pkg>.<output>.overrideAttrs`.
-      disablePythonPackage =
-        drv:
-        extendDerivation (
-          drv.disabled
-          -> throw "${removePrefix namePrefix drv.name} not supported for interpreter ${python.executable}"
-        ) { } drv
-        // {
-          overrideAttrs = fdrv: disablePythonPackage (drv.overrideAttrs fdrv);
-        };
-    in
-    drv: disablePythonPackage (toPythonModule drv);
+  transformDrv = toPythonModule;
 }