diff --git a/pkgs/by-name/gt/gtk-sharp-2_0/builder.sh b/pkgs/by-name/gt/gtk-sharp-2_0/builder.sh
deleted file mode 100644
index 946b65d98a58..000000000000
--- a/pkgs/by-name/gt/gtk-sharp-2_0/builder.sh
+++ /dev/null
@@ -1,9 +0,0 @@
-genericBuild
-
-# !!! hack
-export ALL_INPUTS="$out $pkgs"
-
-find $out -name "*.dll.config" | while read configFile; do
-    echo "modifying config file $configFile"
-    $monoDLLFixer "$configFile"
-done
diff --git a/pkgs/by-name/gt/gtk-sharp-2_0/package.nix b/pkgs/by-name/gt/gtk-sharp-2_0/package.nix
deleted file mode 100644
index 9306c9795ca2..000000000000
--- a/pkgs/by-name/gt/gtk-sharp-2_0/package.nix
+++ /dev/null
@@ -1,83 +0,0 @@
-{
-  stdenv,
-  lib,
-  fetchFromGitHub,
-  pkg-config,
-  mono,
-  glib,
-  pango,
-  gtk2,
-  libxml2,
-  monoDLLFixer,
-  autoconf,
-  automake,
-  libtool,
-  which,
-  fetchpatch,
-}:
-
-stdenv.mkDerivation (finalAttrs: {
-  pname = "gtk-sharp";
-  version = "2.12.45";
-
-  builder = ./builder.sh;
-  src = fetchFromGitHub {
-    owner = "mono";
-    repo = "gtk-sharp";
-    rev = finalAttrs.version;
-    sha256 = "1vy6yfwkfv6bb45bzf4g6dayiqkvqqvlr02rsnhd10793hlpqlgg";
-  };
-
-  patches = [
-    (fetchpatch {
-      url = "https://projects.archlinux.de/svntogit/packages.git/plain/trunk/gtk-sharp2-2.12.12-gtkrange.patch?h=packages/gtk-sharp-2";
-      sha256 = "bjx+OfgWnN8SO82p8G7pbGuxJ9EeQxMLeHnrtEm8RV8=";
-    })
-  ];
-
-  postInstall = ''
-    pushd $out/bin
-    for f in gapi2-*
-    do
-      substituteInPlace $f --replace mono ${mono}/bin/mono
-    done
-    popd
-  '';
-
-  nativeBuildInputs = [
-    pkg-config
-    autoconf
-    automake
-    libtool
-    which
-  ];
-
-  buildInputs = [
-    mono
-    glib
-    pango
-    gtk2
-    libxml2
-  ];
-
-  preConfigure = ''
-    ./bootstrap-${lib.versions.majorMinor finalAttrs.version}
-  '';
-
-  env.NIX_CFLAGS_COMPILE = "-Wno-error=int-conversion";
-
-  dontStrip = true;
-
-  inherit monoDLLFixer;
-
-  passthru = {
-    gtk = gtk2;
-  };
-
-  meta = {
-    description = "Graphical User Interface Toolkit for mono and .Net";
-    homepage = "https://www.mono-project.com/docs/gui/gtksharp";
-    platforms = lib.platforms.unix;
-    license = lib.licenses.gpl2;
-  };
-})
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 52a1816d8275..767529a31000 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1059,6 +1059,7 @@ mapAliases {
   gssdp = throw "'gssdp' (version 1.4) has been removed as it was unmaintained upstream and depended on libsoup 2.4. Consider using `gssdp_1_6` instead"; # Added 2026-06-07
   gtdialog = throw "'gtdialog' has been removed, as it depended on GTK 2. Consider using 'yad' or 'zenity' instead."; # Added 2026-05-22
   gtk-engine-murrine = throw "'gtk-engine-murrine' has been removed, as it depended on GTK2."; # Added 2026-07-22
+  gtk-sharp-2_0 = throw "'gtk-sharp-2_0' has been removed as it provided bindings for the deprecated GTK 2 engine, which is being removed from Nixpkgs."; # Added 2026-08-10
   gtk-sharp-beans = throw "'gtk-sharp-beans' has been removed as it depended on the deprecated GTK 2 engine via Gtk# 2."; # Added 2026-08-10
   gtk_engines = throw "'gtk_engines' has been removed as it was archived upstream and depends on the deprecated GTK2 engine."; # Added 2026-07-30
   gtkcord4 = throw "'gtkcord4' has been renamed to/replaced by 'dissent'"; # Converted to throw 2025-10-27