diff --git a/pkgs/by-name/mi/mitmproxy2swagger/package.nix b/pkgs/by-name/mi/mitmproxy2swagger/package.nix
index db60db153b05..dfde3544f1e9 100644
--- a/pkgs/by-name/mi/mitmproxy2swagger/package.nix
+++ b/pkgs/by-name/mi/mitmproxy2swagger/package.nix
@@ -26,6 +26,7 @@ python3.pkgs.buildPythonApplication (finalAttrs: {
   dependencies = with python3.pkgs; [
     json-stream
     mitmproxy
+    msgpack
     ruamel-yaml
   ];
 
diff --git a/pkgs/development/python-modules/mitmproxy/default.nix b/pkgs/development/python-modules/mitmproxy/default.nix
index 26a965bb66c3..52ce74308c43 100644
--- a/pkgs/development/python-modules/mitmproxy/default.nix
+++ b/pkgs/development/python-modules/mitmproxy/default.nix
@@ -17,7 +17,6 @@
   kaitaistruct,
   ldap3,
   mitmproxy-rs,
-  msgpack,
   nixosTests,
   publicsuffix2,
   pyopenssl,
@@ -53,6 +52,10 @@ buildPythonPackage rec {
   # pins many dependencies way to strict
   pythonRelaxDeps = true;
 
+  # msgpack is unused and was removed upstream:
+  # https://github.com/mitmproxy/mitmproxy/pull/8319
+  pythonRemoveDeps = [ "msgpack" ];
+
   build-system = [ setuptools ];
 
   dependencies = [
@@ -70,7 +73,6 @@ buildPythonPackage rec {
     kaitaistruct
     ldap3
     mitmproxy-rs
-    msgpack
     publicsuffix2
     pyopenssl
     pyparsing