diff --git a/pkgs/by-name/ha/harlequin/package.nix b/pkgs/by-name/ha/harlequin/package.nix
index 406aec8e7876..acfedcc450a5 100644
--- a/pkgs/by-name/ha/harlequin/package.nix
+++ b/pkgs/by-name/ha/harlequin/package.nix
@@ -9,8 +9,8 @@
   writableTmpDirAsHomeHook,
   withPostgresAdapter ? true,
   withBigQueryAdapter ? true,
+  withOdbcAdapter ? true,
 }:
-
 python3Packages.buildPythonApplication (finalAttrs: {
   pname = "harlequin";
   version = "2.16.1";
@@ -61,7 +61,8 @@ python3Packages.buildPythonApplication (finalAttrs: {
       wcwidth
     ]
     ++ lib.optionals withPostgresAdapter [ harlequin-postgres ]
-    ++ lib.optionals withBigQueryAdapter [ harlequin-bigquery ];
+    ++ lib.optionals withBigQueryAdapter [ harlequin-bigquery ]
+    ++ lib.optionals withOdbcAdapter [ harlequin-odbc ];
 
   pythonImportsCheck = [
     "harlequin"
@@ -112,6 +113,12 @@ python3Packages.buildPythonApplication (finalAttrs: {
   ++ lib.optionals (!stdenv.hostPlatform.isx86_64) [
     # Test incorrectly tries to load a dylib/so compiled for x86_64
     "test_load_extension"
+  ]
+  ++ lib.optionals withOdbcAdapter [
+    # harlequin-odbc declares no adapter options (its connection string is a
+    # positional argument), and this test requires every installed adapter to
+    # declare at least one.
+    "test_spec_covers_every_installed_adapter"
   ];
 
   disabledTestPaths = [
diff --git a/pkgs/development/python-modules/harlequin-odbc/default.nix b/pkgs/development/python-modules/harlequin-odbc/default.nix
new file mode 100644
index 000000000000..dbaa4a720fc1
--- /dev/null
+++ b/pkgs/development/python-modules/harlequin-odbc/default.nix
@@ -0,0 +1,52 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  pythonAtLeast,
+  hatchling,
+  duckdb,
+  pyodbc,
+}:
+buildPythonPackage (finalAttrs: {
+  pname = "harlequin-odbc";
+  version = "0.4.0";
+  pyproject = true;
+  __structuredAttrs = true;
+
+  src = fetchFromGitHub {
+    owner = "tconbeer";
+    repo = "harlequin-odbc";
+    tag = "v${finalAttrs.version}";
+    hash = "sha256-U0z7fgBzdL+PRhll6AH4DziqY26kVYA4qkOEbZbWF1g=";
+  };
+
+  build-system = [
+    hatchling
+  ];
+
+  # harlequin loads this adapter as a plugin, so depending on harlequin would
+  # create a cycle, as harlequin can depend on this package.
+  pythonRemoveDeps = [
+    "harlequin"
+  ];
+
+  dependencies = [
+    pyodbc
+  ]
+  ++ lib.optionals (pythonAtLeast "3.14") [
+    duckdb
+  ];
+
+  # The test suite needs harlequin (removed above) and a live database
+  # reachable over ODBC.
+  doCheck = false;
+
+  meta = {
+    description = "A Harlequin adapter for ODBC drivers";
+    homepage = "https://github.com/tconbeer/harlequin-odbc";
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [
+      c4patino
+    ];
+  };
+})
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 411eae4c15fc..23284c8e27ca 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -7547,6 +7547,8 @@ self: super: with self; {
 
   harlequin-bigquery = callPackage ../development/python-modules/harlequin-bigquery { };
 
+  harlequin-odbc = callPackage ../development/python-modules/harlequin-odbc { };
+
   harlequin-postgres = callPackage ../development/python-modules/harlequin-postgres { };
 
   hass-client = callPackage ../development/python-modules/hass-client { };