diff --git a/pkgs/by-name/d-/d-seams/cxxopts-cstdint.patch b/pkgs/by-name/d-/d-seams/cxxopts-cstdint.patch
deleted file mode 100644
index 0ffb08bfab16..000000000000
--- a/pkgs/by-name/d-/d-seams/cxxopts-cstdint.patch
+++ /dev/null
@@ -1,11 +0,0 @@
-diff --git a/src/include/external/cxxopts.hpp b/src/include/external/cxxopts.hpp
---- a/src/include/external/cxxopts.hpp
-+++ b/src/include/external/cxxopts.hpp
-@@ -26,6 +26,7 @@ THE SOFTWARE.
- #define CXXOPTS_HPP_INCLUDED
-
- #include <cctype>
-+#include <cstdint>
- #include <cstring>
- #include <exception>
- #include <iostream>
diff --git a/pkgs/by-name/d-/d-seams/package.nix b/pkgs/by-name/d-/d-seams/package.nix
index 7c325f0571f2..7144673c5862 100644
--- a/pkgs/by-name/d-/d-seams/package.nix
+++ b/pkgs/by-name/d-/d-seams/package.nix
@@ -1,78 +1,57 @@
 {
-  clangStdenv,
-  fetchFromGitHub,
-  fetchpatch,
-  catch2,
-  rang,
-  fmt,
-  yaml-cpp,
-  cmake,
-  eigen,
-  lua,
-  luaPackages,
-  liblapack,
-  blas,
   lib,
-  boost,
-  gsl,
+  stdenv,
+  fetchFromGitHub,
+  meson,
+  ninja,
+  pkg-config,
+  eigen,
+  blas,
+  lapack,
+  catch2_3,
 }:
 
-clangStdenv.mkDerivation rec {
-  version = "1.0.1";
-  pname = "d-SEAMS";
-
-  strictDeps = false;
+stdenv.mkDerivation (finalAttrs: {
+  pname = "d-seams";
+  version = "2.10.0";
 
   src = fetchFromGitHub {
     owner = "d-SEAMS";
     repo = "seams-core";
-    rev = "v${version}";
-    sha256 = "03zhhl9vhi3rhc3qz1g3zb89jksgpdlrk15fcr8xcz8pkj6r5b1i";
+    tag = "v${finalAttrs.version}";
+    hash = "sha256-gtDD0Nc3pC+7eLtH8h+c7j1E9OSGwUWip+Nu0LTOEmw=";
   };
 
-  patches = [
-    (fetchpatch {
-      name = "use_newer_cxxopts_which_builds_with_clang11.patch";
-      url = "https://github.com/d-SEAMS/seams-core/commit/f6156057e43d0aa1a0df9de67d8859da9c30302d.patch";
-      hash = "sha256-PLbT1lqdw+69lIHH96MPcGRjfIeZyb88vc875QLYyqw=";
-    })
-    # Add missing <cstdint> include for uint8_t in vendored cxxopts.
-    ./cxxopts-cstdint.patch
-  ];
-  postPatch = ''
-    substituteInPlace CMakeLists.txt \
-      --replace-fail "cmake_minimum_required(VERSION 3.0 FATAL_ERROR)" "cmake_minimum_required(VERSION 3.10)"
-  '';
+  doCheck = true;
+  strictDeps = true;
+  __structuredAttrs = true;
+
   nativeBuildInputs = [
-    cmake
-    lua
-    luaPackages.luafilesystem
+    meson
+    ninja
+    pkg-config
   ];
+
   buildInputs = [
-    fmt
-    rang
-    yaml-cpp
     eigen
-    catch2
-    boost
-    gsl
-    liblapack
     blas
+    lapack
+    catch2_3
+  ];
+
+  mesonFlags = [
+    "-Dwith_gpulite=disabled"
+    "-Dwith_ira=disabled"
+    "-Dwith_sphericart=disabled"
+    "-Dwith_nauty=disabled"
   ];
 
   meta = {
     description = "Deferred Structural Elucidation Analysis for Molecular Simulations";
-    mainProgram = "yodaStruct";
-    longDescription = ''
-      d-SEAMS, is a free and open-source postprocessing engine for the analysis
-      of molecular dynamics trajectories, which is specifically able to
-      qualitatively classify ice structures in both strong-confinement and bulk
-      systems. The engine is in C++, with extensions via the Lua scripting
-      interface.
-    '';
     homepage = "https://dseams.info";
-    license = lib.licenses.gpl3Plus;
-    platforms = [ "x86_64-linux" ];
-    maintainers = [ ];
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ iedame ];
+    platforms = lib.platforms.linux;
+    mainProgram = "seams";
   };
-}
+})