diff --git a/pkgs/development/python-modules/trx-python/default.nix b/pkgs/development/python-modules/trx-python/default.nix
new file mode 100644
index 000000000000..556cf6118ec9
--- /dev/null
+++ b/pkgs/development/python-modules/trx-python/default.nix
@@ -0,0 +1,65 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  cython,
+  setuptools,
+  setuptools-scm,
+  deepdiff,
+  nibabel,
+  numpy,
+  pytestCheckHook,
+  psutil,
+}:
+
+buildPythonPackage rec {
+  pname = "trx-python";
+  version = "0.3";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "tee-ar-ex";
+    repo = "trx-python";
+    rev = "refs/tags/${version}";
+    hash = "sha256-gKPgP3GJ7QY0Piylk5L0HxnscRCREP1Hm5HZufL2h5g=";
+  };
+
+  build-system = [
+    cython
+    setuptools
+    setuptools-scm
+  ];
+
+  dependencies = [
+    deepdiff
+    nibabel
+    numpy
+  ];
+
+  pythonImportsCheck = [ "trx" ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+    psutil
+  ];
+
+  preCheck = ''
+    export HOME=$TMPDIR
+  '';
+
+  pytestFlagsArray = [ "trx/tests" ];
+
+  disabledTestPaths = [
+    # access to network
+    "trx/tests/test_memmap.py"
+    "trx/tests/test_io.py"
+  ];
+
+  meta = {
+    description = "Python implementation of the TRX file format";
+    homepage = "https://github.com/tee-ar-ex/trx-python";
+    changelog = "https://github.com/tee-ar-ex/trx-python/releases/tag/${version}";
+    license = lib.licenses.bsd2;
+    maintainers = with lib.maintainers; [ ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index e15b48dcb152..c6faf7a1aba5 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -16081,6 +16081,8 @@ self: super: with self; {
 
   truststore = callPackage ../development/python-modules/truststore { };
 
+  trx-python = callPackage ../development/python-modules/trx-python { };
+
   trytond = callPackage ../development/python-modules/trytond { };
 
   ts1-signatures = callPackage ../development/python-modules/ts1-signatures { };