diff --git a/pkgs/development/python-modules/derivative/default.nix b/pkgs/development/python-modules/derivative/default.nix
new file mode 100644
index 000000000000..9079b9aeda13
--- /dev/null
+++ b/pkgs/development/python-modules/derivative/default.nix
@@ -0,0 +1,50 @@
+{
+  lib,
+  fetchFromGitHub,
+  buildPythonPackage,
+
+  # build-system
+  poetry-core,
+
+  # dependencies
+  numpy,
+  scipy,
+  scikit-learn,
+  spectral-derivatives,
+  importlib-metadata,
+
+  # tests
+  pytestCheckHook,
+}:
+
+buildPythonPackage rec {
+  pname = "derivative";
+  version = "0.6.3";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "andgoldschmidt";
+    repo = "derivative";
+    tag = "v${version}";
+    hash = "sha256-vsN1zlD9x0CEOtRIwr/DrtkV+OjiyrI8QL9Z8pB3wrY=";
+  };
+
+  build-system = [ poetry-core ];
+
+  dependencies = [
+    numpy
+    scipy
+    scikit-learn
+    spectral-derivatives
+    importlib-metadata
+  ];
+
+  nativeCheckInputs = [ pytestCheckHook ];
+
+  meta = {
+    description = "Numerical differentiation of noisy time series data";
+    license = lib.licenses.mit;
+    homepage = "https://derivative.readthedocs.io/en/latest/";
+    maintainers = with lib.maintainers; [ conny ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 71d5586068b7..04ea44722856 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -3840,6 +3840,8 @@ self: super: with self; {
 
   depyf = callPackage ../development/python-modules/depyf { };
 
+  derivative = callPackage ../development/python-modules/derivative { };
+
   derpconf = callPackage ../development/python-modules/derpconf { };
 
   desktop-entry-lib = callPackage ../development/python-modules/desktop-entry-lib { };